Keita Miyoshi

This study shows m1A58 regulates tRNA maturation and XRN2-mediated decay in human cells, maintaining tRNA homeostasis.

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

The paper shows that XRN2-dependent decay of mG-hypomodified tRNAs occurs under physiological conditions and is conserved across species.

The paper identifies Osiris genes as key regulators of cuticle nanostructures in Drosophila, showing their expression in cuticle-secreting cells and their role in shaping specific nano-patterns.

This study shows that Mettl1-dependent m7G tRNA modification is essential for spermatogenesis and fertility in Drosophila, as its loss leads to sterility and tRNA instability.