Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration
Michael-John Dolan, Raphael Rakosi-Schmidt, Eric Garcia, Yuesang Lin, Naeem M. Nadaf, Jessica Dixon, Shiran Guo, Nader Morshed, Constanze Depp, Jordan L. Doman, Judy Xia, Henna Jäntti, Beth Stevens, Evan Z. Macosko
This study uses spatial transcriptomics and single-nucleus RNA-seq to analyze remyelination dynamics, identifying an interferon-responsive glial state that coordinates immune infiltration and oligodendrocyte differentiation.
bioRxiv · Apr 22, 2025 · PreprintNeuroscience