Comparative analysis of microglia-targeted AAVs reveals capsid choice drives efficiency in vitro but has limited impact in vivo
Saša Jereb, Lia R. D’Alessandro, Nader Morshed, Margery Chen, Rafaela Sartore, Zengpeng Han, Jordan E. McKinney, Pamela P. Brauer, John W. Harvey, Matthew Demers, Dara Cuffe, Raphael Rakosi-Schmidt, Luira Leite, Youtong Huang, Qingxia Zheng, , Benjamin E. Deverman
The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.
bioRxiv · Aug 5, 2026 · PreprintNeuroscience