Michael-John Dolan

Protein-guided RNA barcoding links transcriptomes to synaptic architecture

The paper introduces Synapse-seq, a method to link transcriptomes to synaptic architecture by using protein-guided RNA barcoding, revealing new insights into neural connectivity and cell type-specific dendritic structures.

Spatial transcriptomics of compartmentalised inflammation in multiple sclerosis

The paper uses spatial transcriptomics to analyze inflammation in multiple sclerosis, identifying unique immune signatures in tertiary lymphoid-like structures.

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

This study uses spatial transcriptomics and single-nucleus RNA-seq to analyze remyelination dynamics, identifying an interferon-responsive glial state that coordinates immune infiltration and oligodendrocyte differentiation.

A split-GAL4 driver line resource for Drosophila neuron types

The paper describes a collection of split-GAL4 driver lines for targeting specific neuron types in Drosophila, enabling functional and molecular studies.

A resource for generating and manipulating human microglial states in vitro

This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.

HiDDEN: A machine learning label refinement method for detection of disease-relevant populations in case-control single-cell transcriptomics

HiDDEN refines case-control labels in single-cell transcriptomics to detect disease-relevant cell populations, improving detection of subtle perturbations in simulated and real datasets.

Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output.

Geosmin avoidance in Drosophila runs from a labelled line at the periphery into a distributed central representation spanning 80 third-order cell types, then into specific descending neurons.

Neuronal circuitry underlying female aggression in Drosophila

This study identifies neuronal circuits in Drosophila that regulate female aggression through optogenetic manipulation and connectomic analysis.

Functional and Anatomical Specificity in a Higher Olfactory Centre

The paper identifies 165 cell types in the Drosophila lateral horn and shows that 33 of them have stereotyped odor responses, revealing principles of odor categorization in a higher olfactory center.

Communication from learned to innate olfactory processing centers is required for memory retrieval in Drosophila

The paper identifies two LH cell-types in Drosophila that are required for aversive memory retrieval and show that memory information is passed from the mushroom body to the lateral horn.

Neurogenetic dissection of the Drosophila innate olfactory processing center

The paper generates split-GAL4 driver lines to map and functionally characterize 82 cell types in the Drosophila lateral horn, revealing connectivity with mushroom bodies and identifying cell types that influence behavior.

Ultra fast tissue staining with chemical tags

This paper introduces a chemical tagging method for rapid, low-background labeling of thick tissues, demonstrating 100x faster staining of whole-mount fly brains.