Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy
Lior Goldberg, Eric R. Haas, Jiaqi Wu, Bryan Garcia, Ryan Z. Urak, Vibhuti Vyas, Ruby Espinosa, Tamara Munoz, Shirley Bierkatz, Khyatiben V. Pathak, Nathaniel P. Hansen, Patrick Pirrotte, Jyotsana Singhal, James Lester Figarola, Ricardo Zerda Noriega, , Xiuli Wang
This study identifies immunometabolic factors in CD19 CAR T cells that predict long-term response in B-ALL patients and suggests mTOR inhibition as a strategy to enhance anti-tumor activity.
Nature Communications · Feb 20, 2026Peer-reviewedImmunology