Microbial valerate is associated with CAR T dysbiosis and its supplementation enhances CAR T function in B-cell lymphoma
Lubna Rehman, Wenting Song, Abdur Rehman, Kamini Singh, Shiv Govind Rawat, Faezeh Darbaniyan, Cao Cuong Le, Federico Mario Aletti, Jinsheng Weng, Jingwei Liu, Xiayoun Cheng, Yongfu Tang, Sridevi Patchva, Matthew D. Richard, Fuliang Chu, , Neeraj Y. Saini
This study links low stool valerate to CAR T-cell dysfunction in B-cell lymphoma and shows valerate supplementation improves CAR T function.
bioRxiv · Sep 3, 2026 · PreprintCancer Biology