Christopher R. Flowers

This study links low stool valerate to CAR T-cell dysfunction in B-cell lymphoma and shows valerate supplementation improves CAR T function.

The paper establishes a PDX repository of large B-cell lymphoma models capturing clinical and molecular diversity, including post-CART19 progression cases.

The paper identifies H3 serine 28 phosphorylation as a mechanism driving chromatin derepression and immune cell fate transitions by disrupting repressive chromatin domains.

MASH identifies high-dimensional mediators in survival analysis, showing cigarette smoking mediates 51.1% of coronary heart disease risk via five metabolites.

CASi is a framework for analyzing multi-timepoint scRNA-seq data, enabling cell annotation, novel cell type detection, population evolution visualization, and temporal differential gene identification.

This paper introduces a method for imputing censored survival data to improve machine learning analysis in biomedical research.

This study finds that clonal hematopoiesis mutations, particularly in DNMT3A, TET2, and ASXL1, are linked to increased toxicity in patients undergoing anti-CD19 CAR T-cell therapy for large B-cell lymphoma.