Author

Christoph K. Stein‐Thoeringer

Universitätsklinikum TübingenORCID 0000-0002-8020-6986Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Abdur RehmaniD· 1 shared Abhinav K. JainiD· 1 shared Aistė Skorupskaitė· 1 shared Alexander VisekrunaiD· 1 shared Cao Cuong Le· 1 shared Christopher R. FlowersiD· 1 shared Dirk Hans BuschiD· 1 shared Elizabeth J. ShpalliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abdur RehmanORCID

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2 papers

Recent·Most cited

Microbial valerate is associated with CAR T dysbiosis and its supplementation enhances CAR T function in B-cell lymphoma

Lubna Rehman, Wenting Song, Abdur Rehman, Kamini Singh, Shiv Govind Rawat, Faezeh Darbaniyan, Cao Cuong Le, Federico Mario Aletti, Jinsheng Weng, Jingwei Liu, Xiayoun Cheng, Yongfu Tang, Sridevi Patchva, Matthew D. Richard, Fuliang Chu, , Neeraj Y. Saini

This study links low stool valerate to CAR T-cell dysfunction in B-cell lymphoma and shows valerate supplementation improves CAR T function.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz, Noémie Leblay, Xiaoli-Kat Yuan, M. Larrayoz, Teresa Lozano, Linda Warmuth, Matthias A. Fante, Aistė Skorupskaitė, Teng Fei, Maria Bromberg, Patxi San Martín‐Úriz, Juan R. Rodríguez-Madoz, , Maik Luu

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

bioRxiv · Aug 19, 2024 · PreprintImmunology