This study identifies TGM2-mediated histone serotonylation as a cardioprotective epigenetic mechanism in HFpEF, showing its role in stress response and cardiac function.

bioRxiv · Jul 1, 2026 · PreprintPathology

Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves

Yasuyuki Fujii, Shu Taira, Keisuke Shinoda, Yuki Yamato, Kazuki Sakata, Orie Muta, Yuta Osada, Ashiyu Ono, Toshiya Matsushita, Mizuki Azumi, Hitomi Shikano, Keiko Abe, Vittorio Calabrese, Naomi Osakabe

This study shows that astringent flavanols activate the locus coeruleus-noradrenergic system and related neuroendocrine axes, enhancing locomotion and memory in mice.

Current Research in Food Science · Jan 1, 2025Peer-reviewedSynthetic Biology

Distinct classes of antidepressants commonly act to shape pallidal structure and function in mice

Yoshifumi Abe, Yuki Sugiura, Rae Maeda, Shu Taira, Keisuke Yoshida, Daisuke Ibi, Satoru Moritoh, Kenji Hashimoto, Sho Yagishita, Kenji F. Tanaka

The paper shows that different antidepressants induce similar structural and molecular changes in the pallidum of mice, suggesting a common mechanism in their antidepressant effects.

bioRxiv · Sep 23, 2024 · PreprintNeuroscience

Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia

Yoshifumi Abe, Sho Yagishita, Hiromi Sano, Yuki Sugiura, Masanori Dantsuji, T. Suzuki, Ayako Mochizuki, Daisuke Yoshimaru, Junichi Hata, Mami Matsumoto, Shu Taira, Hiroyoshi Takeuchi, Hideyuki Okano, Nobuhiko Ohno, Makoto Suematsu, , Kenji F. Tanaka

This paper identifies shared GABA transmission pathology in L-DOPA-induced and tardive dyskinesia models through structural and functional analysis of striatal neurons.

Cell Reports Medicine · Sep 28, 2023Peer-reviewedNeuroscience