Satoshi Waguri

This study identifies TGM2-mediated histone serotonylation as a cardioprotective epigenetic mechanism in HFpEF, showing its role in stress response and cardiac function.

The paper shows that KEAP1 retention in p62 bodies and NRF2 activation cause liver damage when autophagy is impaired, and that blocking p62-KEAP1 interactions reduces this damage.

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

The paper identifies a distinct genetic subgroup of low-grade meningiomas through gene expression profiling, suggesting potential for improved diagnosis and treatment.