Ketone-body receptor GPR109A suppresses hepatic inflammation via gut-liver axis regulation
Akari Nishida, Shota Nishikawa, River Budau, Mayu Yamano, Ryuji Ohue‐Kitano, Takako Ikeda, Nobuo Sasaki, Ikuo Kimura
This study shows that GPR109A protects the liver from inflammation during the ketogenic diet by maintaining intestinal barrier integrity through the gut-liver axis.
bioRxiv · Aug 21, 2025 · PreprintPhysiology