Ikuo Kimura

This study maps the expression of PAQR6 and PAQR8 in ruminant reproductive tissues using antibodies and qPCR, showing their localization and dynamic gene expression changes during pregnancy.

The paper identifies cell-type-specific expression patterns of classical and membrane progesterone receptors at the human maternal-fetal interface using single-cell and spatial transcriptomic data.

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

The paper shows that eosinophils modulate neutrophil differentiation into pathogenic Siglec-Fhi neutrophils via GPR43, exacerbating allergic airway inflammation.

This study shows hexanoic acid improves metabolic health in mice on a high-fat diet by reducing weight gain, fat accumulation, and glucose intolerance.

This study shows that GPR109A protects the liver from inflammation during the ketogenic diet by maintaining intestinal barrier integrity through the gut-liver axis.

This study shows that maternal progesterone and adipose mPRε regulate the embryonic nutritional state by affecting glucose provision and metabolic outcomes in offspring.

This study shows that GPR164 deletion in mice causes intestinal barrier dysfunction, Wnt/β-catenin signaling disruption, and IBD-like symptoms, suggesting GPR164 as a therapeutic target for IBD.