Nobuo Sasaki

Microbiota-derived pantothenic acid rapidly restores colonic mucus barrier after antibiotic-induced dysbiosis

This study identifies pantothenic acid as a microbial metabolite that rapidly restores colonic mucus barrier integrity after antibiotic-induced dysbiosis in mice.

Maternal progesterone signaling establishes lifelong oral homeostasis

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

Ketone-body receptor GPR109A suppresses hepatic inflammation via gut-liver axis regulation

This study shows that GPR109A protects the liver from inflammation during the ketogenic diet by maintaining intestinal barrier integrity through the gut-liver axis.

The pivotal role of a novel free fatty acid receptor GPR164 in the intestinal barrier function

This study shows that GPR164 deletion in mice causes intestinal barrier dysfunction, Wnt/β-catenin signaling disruption, and IBD-like symptoms, suggesting GPR164 as a therapeutic target for IBD.