A Novel Hydrogen Polysulfide Donor Alleviates Neuropathic Pain by Enhancing A-Type Potassium Currents via LIMK1-Cofilin Mediated Interaction between Filamin A and Kv4.2
Ting Kang, Jierui Yan, Shirong Lai, Shouwei Tao, Chunxia Chen, Zhihua Cao, Fei Yan, Yanwen Ding, Xuehan Li, Bowen Ke
This paper develops a novel H2S2 donor, HPD1, which alleviates neuropathic pain by enhancing A-type potassium currents through a LIMK1-cofilin-Filamin A-Kv4.2 mechanism.
bioRxiv · May 28, 2026 · PreprintPharmacology & Toxicology