Bowen Ke

The paper introduces MASCOT, a multi-agent framework for molecular optimization, which improves anesthetic candidates with better safety and recovery properties.

This paper develops a novel H2S2 donor, HPD1, which alleviates neuropathic pain by enhancing A-type potassium currents through a LIMK1-cofilin-Filamin A-Kv4.2 mechanism.

The paper identifies BN3 as a broad-spectrum agent that accelerates emergence from general anesthesia by targeting a VTA glutamatergic arousal circuit.

This study identifies AH001 as a potent TRPV4 inhibitor, revealing its mechanism and demonstrating its analgesic effects in pain models.

This study develops a multivalent scaffold targeting LRP1 at the BBB to reduce Aβ deposits and cognitive decline in AD model mice.

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to classify adult human spinal cord neurons into 21 subclusters and compare them with mouse data, revealing similarities and sex differences.