Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model
Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Rizwan Hasan Khan, Justin L. Wang, Lauren C. Guttman, Devanik Biswas, Abhishek Pasupuleti, Akansha Aggarwal, Shraddha Pandya, Shih-Ching Chou, Nikhil Panicker, Abhay Monghekar, Marilyn Albert, Lynn M. Bekris, , Valina Lynn Dawson
This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.
bioRxiv · Sep 6, 2025 · PreprintNeuroscience