Author

Shih-Ching Chou

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:non-human primate· 2 Assay:proteomics· 1

Frequent Co-Authors

Bradford M. ElmeriD· 2 shared Christian MuelleriD· 2 shared Devanik BiswasiD· 2 shared Dhiman Ghosh· 2 shared Erik Wischhof· 2 shared Jie BuiD· 2 shared Lilu Guo· 2 shared Mahmud HossainiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Bradford M. ElmerORCID

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4 papers

Recent·Most cited

Reactive Astrocytes Drive Extracellular Acidification to Mediate α-Synuclein Neurodegeneration

Jae‐Jin Song, Hyejin Park, YuRee Choi, Taekyung Ryu, Jisu Shin, Seo-Hyun Kim, Albert Park, Justin Wang, Devanik Biswas, Shih-Ching Chou, Shinwon Ha, Yura Jang, Yu Jung Shin, Hao Wen Chen, Ingie Hong, , Tae‐In Kam

This study identifies a mechanism by which reactive astrocytes drive neurodegeneration in synucleinopathies through extracellular acidification and neuronal ASIC1a activation.

bioRxiv · Mar 4, 2026 · PreprintNeuroscience

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model

Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Rizwan Hasan Khan, Justin L. Wang, Lauren C. Guttman, Devanik Biswas, Abhishek Pasupuleti, Akansha Aggarwal, Shraddha Pandya, Shih-Ching Chou, Nikhil Panicker, Abhay Monghekar, Marilyn Albert, Lynn M. Bekris, , Valina Lynn Dawson

This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.

bioRxiv · Sep 6, 2025 · PreprintNeuroscience

AAV gene therapy for GBA-PD and Gaucher Disease

Swathi Ayloo, Jae Cheon Ryu, Shih-Ching Chou, Lydia Blatnik, Erik Wischhof, Jie Bu, Lilu Guo, Mahmud Hossain, Dhiman Ghosh, William McCarty, Ann Byrne, Lilly Chai, J T Clarke, Can Kayatekin, Bailin Zhang, , Shyam S. Ramachandran

This paper describes an AAV-mediated gene therapy strategy for GBA1-PD and Gaucher Disease, demonstrating robust GCase replenishment and cross-correction in preclinical models.

bioRxiv · Jun 17, 2025 · PreprintNeuroscience

AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy

Shyam Ramachandran, Jeffery Ardinger, Jie Bu, MiAngela Ramos, Lilu Guo, Dhiman Ghosh, Mahmud Hossain, Shih-Ching Chou, Yao Chen, Erik Wischhof, Swathi Ayloo, Roger Trullo, Yuxia Luo, Jessica M. Hogestyn, Daniel DuBreuil, , Christian Mueller

This study develops an AAV vector for ARSA gene replacement in MLD, showing improved brain biodistribution and therapeutic effects in mice and non-human primates.

bioRxiv · Mar 12, 2025 · PreprintNeuroscience