Targeting Cellular Pseudo-Senescence to Overcome PARP inhibitors Resistance in BRCA1 -Mutated Breast Cancer
Zhen Tian, Srinivas Chatla, Shreya Indulkar, Dongwook Kim, Xiaoyu Wei, Yun Liao, Dan Yang, Anthony Pompetti, Gennaro Calendo, Congli Wang, Tina Bocker Edmonston, Zhenkun Lou, Tomasz Skórski, Liewei Wang, Jian Yuan Huang
This study identifies ZNF251 deficiency as a driver of PARP inhibitor resistance in BRCA1-mutant breast cancer, showing that targeting pseudo-senescence with senomorphic or senolytic therapies can overcome resistance.
bioRxiv · Jun 26, 2026 · PreprintCancer Biology