Cancer BiologybioRxivPreprint
Targeting Cellular Pseudo-Senescence to Overcome PARP inhibitors Resistance in BRCA1 -Mutated Breast Cancer
Zhen Tian, Srinivas Chatla, Shreya Indulkar…·Jian Yuan Huang
This study identifies ZNF251 deficiency as a driver of PARP inhibitor resistance in BRCA1-mutant breast cancer, showing that targeting pseudo-senescence with senomorphic or senolytic therapies can overcome resistance.
DOI 10.64898/2026.06.25.734617