Gennaro Calendo

TEDEdb: a large-scale resource and multi-cohort analysis of transposable element differential expression in cancer

The paper re-analyzes over 7,000 RNA-seq samples to study transposable element differential expression in cancer and finds TE expression is more prone to batch effects and can be induced by various compounds.

New iPSC resource with long-read whole genome sequencing characterizations for enhanced in vitro modeling

The paper introduces a new iPSC resource with long-read whole-genome sequencing data for in vitro modeling and genomic analysis.

Ribonucleotide Reductase Inhibition Overcomes FLT3 Inhibitor Resistance in Acute Myeloid Leukemia

This paper identifies RNR inhibition as a strategy to overcome FLT3 inhibitor resistance in FLT3ITD+ AML by reversing resistance mechanisms and enhancing therapeutic efficacy.

Targeting Cellular Pseudo-Senescence to Overcome PARP inhibitors Resistance in BRCA1 -Mutated Breast Cancer

This study identifies ZNF251 deficiency as a driver of PARP inhibitor resistance in BRCA1-mutant breast cancer, showing that targeting pseudo-senescence with senomorphic or senolytic therapies can overcome resistance.

Sex chromosomes and sex hormones contribute jointly and independently to sex biases in cardiac development.

The paper investigates how sex chromosomes and gonadal hormones jointly and independently influence sex-biased gene expression in cardiac development across multiple stages.

Four Core Genotypes Mice Exhibit Quantitative Differences in T and B Cell Subpopulations compared to Wild-type Mice.

The paper compares T and B cell subpopulations in Four Core Genotypes mice to wild-type mice, finding sex chromosome effects on immune cell populations.

YAP1 Depletion Enhances TAZ and its Complexation with TEAD4 and AP-1 Heterodimer C-JUN/FOSB to Promote Gastric Cancer Progression and Metastases

This study shows that inhibiting both YAP1 and TAZ in gastric cancer peritoneal metastases reduces tumor growth and progression by blocking their interactions with TEAD4 and AP-1 complexes.

CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signaling

ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer

This study identifies ZNFX1 as a master regulator of epigenetically-induced pathogen mimicry and inflammasome signaling in ovarian cancer, linking its expression to disease progression and survival.

ursaPGx: a new R package to annotate pharmacogenetic star alleles using phased whole genome sequencing data

Star allele search: a pharmacogenetic annotation database and user-friendly search tool of publicly available 1000 Genomes Project biospecimens

The paper introduces a pharmacogenetic annotation database and search tool for 1000 Genomes Project biospecimens, enabling allele haplotype and diplotype analysis and supporting clinical PGx assay development.