Macrophage Immune-Competent Colon Assembloids for Functional Interrogation of Neuroinflammation-Induced Colonic Dysmotility
Claudia A. Collier, Karla Ortega-Sandoval, Aelita Salikhova, Shrinarayanee Rengarajan, Anvitha Tharakesh, Alana Aristimuno Millan, Shanthi Srinivasan, Shreya A. Raghavan
This study introduces an immune-competent colon assembloid model to investigate how neuroinflammation affects colonic motility, finding impaired neuronal regeneration and smooth muscle remodeling as key mechanisms.
Gastro Hep Advances · Jan 1, 2026Peer-reviewedBioengineering