Shanthi Srinivasan

This study introduces an immune-competent colon assembloid model to investigate how neuroinflammation affects colonic motility, finding impaired neuronal regeneration and smooth muscle remodeling as key mechanisms.

The paper identifies that post-inflammatory GI dysmotility results from ENS remodeling driven by monocyte recruitment and neuroinflammation, which can be prevented by enhancing HIF1 signaling in enteric neurons.

This study shows that dietary fiber and microbiome-derived metabolites protect the enteric nervous system after spinal cord injury by modulating immune signaling.