Author

Shruthi Nyshadham

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Brant E. IsaksoniD· 3 shared Luke S. DunawayiD· 3 shared Melissa A. LuseiD· 3 shared Miriam Margherita Cortese-KrottiD· 2 shared Pooneh BagheriD· 2 shared Skylar A. LoebiD· 2 shared Timothy M. SveeggeniD· 2 shared Wyatt J. SchugiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMolecular Biology

Brant E. IsaksonORCID

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Author profile →

3 papers

Recent·Most cited

Arterial iron regulates vasodilation during anemia via endothelial holo-alpha globin

Luke S. Dunaway, Shruthi Nyshadham, Wyatt J. Schug, Skylar A. Loeb, Brooke L. O’Donnell, Zuzanna J. Juśkiewicz, Nasim A Abib, Melissa A. Luse, Macy E. Stahl, Timothy M. Sveeggen, Pooneh Bagher, Jason Allen, Adam N. Goldfarb, Brant E. Isakson

This study shows arterial iron deficiency affects vasodilation by altering endothelial holo-alpha globin levels and NO signaling in female mice, but not in males.

bioRxiv · Dec 12, 2025 · PreprintPhysiology

Nitrosation of CD36 regulates endothelial function and serum lipids

Melissa A. Luse, Wyatt J. Schug, Luke S. Dunaway, Shruthi Nyshadham, Skylar A. Loeb, Alicia de Alencar Carvalho, Rachel Tessema, Caitlin M. Pavelec, T.C. Stevenson Keller, Xiaohong H. Shu, Claire A. Ruddiman, Anna Kosmach, Timothy M. Sveeggen, Ray Mitchell, Pooneh Bagher, , Brant E. Isakson

The paper shows nitrosation of CD36 by nitric oxide prevents endothelial lipid uptake and maintains function in obesity.

Arteriosclerosis Thrombosis and Vascular Biology · Apr 17, 2025Peer-reviewedMolecular Biology

Loss of endothelial cell heterogeneity in arteries after obesogenic diet

Luke S. Dunaway, Melissa A. Luse, Shruthi Nyshadham, Gamze Betul Bulut, Gabriel F. Alencar, Nicholas W. Chavkin, Miriam Margherita Cortese-Krott, Karen K. Hirschi, Brant E. Isakson

The paper investigates how an obesogenic diet affects endothelial cell heterogeneity in arteries, finding convergence in transcriptional profiles between mesenteric and adipose arterial endothelial cells in obesity.

bioRxiv · Jun 23, 2023 · PreprintMolecular Biology