Karen K. Hirschi

This study identifies nine endothelial cell types in the developing murine kidney using snucRNA-Seq and validates novel biomarkers through RNAScope.

The paper investigates how an obesogenic diet affects endothelial cell heterogeneity in arteries, finding convergence in transcriptional profiles between mesenteric and adipose arterial endothelial cells in obesity.

This study uses longitudinal imaging to show how vascular maturation and maintenance occur in live mouse skin through vessel regression, EC rearrangement, and VEGFR2 signaling.

This study shows that Cx43-mediated interactions between neural stem cells and endothelial cells in the SVZ regulate NSC quiescence and neurogenesis.

The paper uses long-read proteogenomics to characterize protein isoform diversity in HUVECs, identifying novel transcripts and isoforms with potential functional implications.

This study shows that endothelial cell cycle states determine arterial-venous fate, with early G1 for venous and late G1 for arterial specification.

The paper benchmarks variant callers on long-read RNA-seq data and proposes a pipeline to improve their performance using spliced alignment files.

The paper shows that N-glycan modifications regulate endothelial-to-hematopoietic transition by affecting glycosylation enzymes and HSPC production.