IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia
Lyna E.S. Kabbani, Shruti Kapoor, Gunjan Sharma, Martin E Gutierrez, Zachary T. Neeb, Amit Jaiswal, Alexander J. Ritter, Sol J. Katzman, Jordyn E Feldman, Dinesh S. Rao, Jeremy R. Sanford
This study identifies IGF2BP3's role in modulating miRNA targeting in MLL-AF4 leukemia by competing with AGO2 for 3'-UTR binding, thereby reducing miR-181a-mediated repression of oncogenic mRNAs.
bioRxiv · Oct 10, 2025 · PreprintCancer Biology