Cancer BiologybioRxivPreprint
IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia
Lyna E.S. Kabbani, Shruti Kapoor, Gunjan Sharma…·Jeremy R. Sanford
This study identifies IGF2BP3's role in modulating miRNA targeting in MLL-AF4 leukemia by competing with AGO2 for 3'-UTR binding, thereby reducing miR-181a-mediated repression of oncogenic mRNAs.
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