Author
University of California, Santa CruzORCID 0000-0003-3156-3159Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Holly C. Beale, Victor Tse, J.Y. Lee…·Anne Michele Slavotinek
The paper identifies a pathogenic splice site variant in DEGS1 causing aberrant splicing and loss of enzyme activity in individuals with HLD18.
Lyna E.S. Kabbani, Shruti Kapoor, Gunjan Sharma…·Jeremy R. Sanford
This study identifies IGF2BP3's role in modulating miRNA targeting in MLL-AF4 leukemia by competing with AGO2 for 3'-UTR binding, thereby reducing miR-181a-mediated repression of oncogenic mRNAs.
Gunjan Sharma, Martin E Gutierrez, Anthony E. Jones…·Dinesh S. Rao
This study shows IGF2BP3 regulates RNA methylation by altering cellular metabolism to increase SAM production, enhancing m6A modifications and gene expression in leukemia.
Victor Tse, Guillermo Chacaltana, Martin E Gutierrez…·Jeremy R. Sanford
The paper identifies a three-way junction structure in intron 15 that affects F8 pre-mRNA splicing and shows that antisense oligonucleotides targeting this structure can rescue splicing defects in Hemophilia A.