Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin
Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shuming Liu, Geon Ho Jeong, Yayun Xie, Duc Minh Duong, Nicholas T. Seyfried, Ivaylo N. Ivanov, , Jun Yin
This study develops an orthogonal ubiquitin transfer cascade to profile Parkin substrates, revealing roles in DNA replication, protein transport, and mitophagy.
iScience · Jun 17, 2025Peer-reviewedBiochemistry