Author

Ivaylo N. Ivanov

Georgia State UniversityORCID 0000-0002-5306-1005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

Bradley R. Kossmann· 2 shared Chunli YaniD· 2 shared Leonardo Farias SerafimiD· 2 shared Andrew S. Arvai· 1 shared Angela M. MabbiD· 1 shared Anil K. Mantha· 1 shared Anita H. CorbettiD· 1 shared Areetha D’SouzaiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Bradley R. Kossmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Systematic comparison of pathogenic variants of the RNA exosome gene EXOSC3/RRP40 in Saccharomyces cerevisiae reveals variant-specific functional consequences

Milo B. Fasken, Sara W. Leung, Leonardo Farias Serafim, Chunli Yan, Madison L. Intemann, Dustin L. Gable, Kristin W. Baranano, Ivaylo N. Ivanov, Homa Ghalei, Anita H. Corbett

The paper systematically analyzes eight pathogenic EXOSC3 variants in yeast to determine their functional consequences on RNA exosome function.

bioRxiv · Aug 2, 2026 · PreprintGenetics

Orchestrated metal ion repositioning defines the dynamic catalytic strategy of the essential DNA repair nuclease APE1

Leonardo Farias Serafim, Susan Tsutakawa, Andrew S. Arvai, Bradley R. Kossmann, Anil K. Mantha, Rachel Abbotts, David M. Wilson, SANKAR P. MITRA, John A. Tainer, Ivaylo N. Ivanov

This study reveals the dynamic catalytic mechanism of APE1 using a moving metal ion strategy, showing how Mg2+ repositioning enables efficient DNA repair without forming a pentavalent intermediate.

bioRxiv · May 14, 2026 · PreprintBiochemistry

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair

Mihyun Kim, Eunwoo Jeong, Jiyoung Park, Areetha D’Souza, Miaw-Sheue Tsai, Chunli Yan, Ivaylo N. Ivanov, Walter Chazin, Hyun Suk Kim, Orlando D. Schärer

This study investigates the role of XPG interactions with TFIIH subunits p62 and XPD in nucleotide excision repair, showing their importance for catalytic activity and incision initiation.

Nucleic Acids Research · Jan 23, 2026Peer-reviewedBiochemistry

Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin

Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shuming Liu, Geon Ho Jeong, Yayun Xie, Duc Minh Duong, Nicholas T. Seyfried, Ivaylo N. Ivanov, , Jun Yin

This study develops an orthogonal ubiquitin transfer cascade to profile Parkin substrates, revealing roles in DNA replication, protein transport, and mitophagy.

iScience · Jun 17, 2025Peer-reviewedBiochemistry