TSHR-targeting nucleic acid aptamer treats Graves' ophthalmopathy via novel allosteric inhibition
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, , Wencan Wu
This study develops YC3, a TSHR-targeting aptamer that inhibits TSHR signaling and treats Graves' ophthalmopathy by binding to a novel allosteric site.
Advanced Science · Oct 7, 2025Peer-reviewedBiochemistry