Functional impact of pathogenic Runt domain mutations in Runx2 on skeletal and dental development in cleidocranial dysplasia
Saki Ogawa, Shinnosuke Higuchi, Yuki Yoshimoto, Mari Hoshino, Shigenori Miura, Atsuko Hamada, Hitomi Watanabe, Tetsushi Sakuma, Kadi Hu, Shun Ogata, Kenta Uchibe, Katsumi Fujimoto, Takashi Yamamoto, Tetsuji Okamoto, Ryo Kunimatsu, , Chisa Shukunami
This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.
bioRxiv · Jun 18, 2025 · PreprintGenetics