Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia
Adela Constantinescu‐Bercu, Koval E. Smith, Shuo Yi Wong, Mattia Ballerini, Alessia Nastro, Benjamin G. Wiggins, Daniela Pirri, A. K. C. Li, Juun Evers, Olga Tsiamita, Matthew Dibble, Charis Pericleous, Koralia E. Paschalaki, Graeme M. Birdsey, Michael Laffan, , ANNA MARIA RANDI
This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.
bioRxiv · Sep 9, 2025 · PreprintCell Biology