ANNA MARIA RANDI

ZONAB regulates DNA methylation and mitochondrial function to control endothelial cell senescence

This study shows ZONAB regulates endothelial cell senescence by controlling DNA methylation and mitochondrial function, impacting angiogenesis and vascular health.

Targeting endothelial ERG to mitigate vascular regression and neuronal ischemia in retinopathies

This study shows that overexpressing ERG in endothelial cells prevents vascular regression and neuronal damage in OIR models, suggesting ERG as a potential therapeutic target for retinopathies.

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

A Microfluidic Blood Vessel-On-Chip Model of Thrombosis

This paper develops a thrombus-on-chip model with endothelium and whole blood to study thrombosis, showing TNF-activation increases platelet adhesion and fibrin deposition.