Author

Michael Laffan

Imperial College LondonORCID 0000-0002-8268-3268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Suthesh SivapalaratnamiD· 2 shared A. K. C. Li· 1 shared Adela Constantinescu‐BercuiD· 1 shared Alessia Nastro· 1 shared Alexander ToliosiD· 1 shared Andrew David MumfordiD· 1 shared ANNA MARIA RANDIiD· 1 shared Benjamin G. WigginsiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Suthesh SivapalaratnamORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 9, 2025

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

Adela Constantinescu‐Bercu, Koval E. Smith, Shuo Yi Wong…·ANNA MARIA RANDI

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

1 citation

humanproteomics

𝕏 PostBluesky

GeneticsbioRxivPreprintDec 21, 2018

Diagnostic high-throughput sequencing of 2,390 patients with bleeding, thrombotic and platelet disorders

Kate Downes, Karyn Mégy, Daniel Duarte…·Kathleen Freson

The paper reports a diagnostic HTS test for bleeding, thrombotic, and platelet disorders, identifying molecular diagnoses in 897 out of 2,390 patients.

DOI 10.1101/504142

humanwhole-exome sequencing

𝕏 PostBluesky