Author

Benjamin G. Wiggins

Imperial College LondonORCID 0000-0001-5215-2004Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. C. Li· 1 shared Adela Constantinescu‐BercuiD· 1 shared Alessia Nastro· 1 shared ANNA MARIA RANDIiD· 1 shared Charis PericleousiD· 1 shared Daniela PirriiD· 1 shared Graeme M. BirdseyiD· 1 shared Juun Evers· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

A. K. C. Li

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1 paper

Recent·Most cited

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut Angiodysplasia

Adela Constantinescu‐Bercu, Koval E. Smith, Shuo Yi Wong, Mattia Ballerini, Alessia Nastro, Benjamin G. Wiggins, Daniela Pirri, A. K. C. Li, Juun Evers, Olga Tsiamita, Matthew Dibble, Charis Pericleous, Koralia E. Paschalaki, Graeme M. Birdsey, Michael Laffan, , ANNA MARIA RANDI

This study shows that VWF deficiency increases Angpt-2 expression via the Tie2-Akt-FOXO1 pathway, leading to vascular defects in the gut and suggesting Angpt-2 inhibitors could treat VWD-related bleeding.

bioRxiv · Sep 9, 2025 · PreprintCell Biology