ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center
Ying Guan, Mariia Mikhova, Zhuo Yang…·Xi Chen
The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.
DOI 10.1073/pnas.2625638123