Author

Xi Chen

Boston Children's HospitalORCID 0000-0002-8066-3394Unclaimed ORCID profile · follow to get notified of new preprints

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Xi Chen12 papers · AstraZeneca (United States)

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

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Adam Yongxin YeiD· 1 shared David G. SchatziD· 1 shared Frederick W. AltiD· 1 shared Jianshu Wang· 1 shared Kai Xu· 1 shared Mariia MikhovaiD· 1 shared Shuxian Xie· 1 shared Taimor Williams· 1 shared

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1 shared paperImmunology

Adam Yongxin YeORCID

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1 paper

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ImmunologyProceedings of the National Academy of SciencesPeer-reviewedSep 28, 2026

Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center

Ying Guan, Mariia Mikhova, Zhuo Yang…·Xi Chen

The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.

DOI 10.1073/pnas.2625638123

humanDNA methylation

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