Human antibody heavy chain variable region exon interacts with 3' regulatory region to form a stable somatic hypermutation center
Ying Guan, Mariia Mikhova, Zhuo Yang, Kai Xu, Shuxian Xie, Xin Lin, Adam Yongxin Ye, Taimor Williams, Jianshu Wang, David G. Schatz, Frederick W. Alt, Xi Chen
The paper demonstrates that a human antibody heavy chain variable region exon forms a stable somatic hypermutation center (SHM-C) through interaction with 3' regulatory regions, supporting AID access and SHM in non-dividing cells.
Proceedings of the National Academy of Sciences · Sep 28, 2026Peer-reviewedImmunology