THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression
Shreya Budhiraja, Umme H Faisal, Shivani Baisiwala, Rafał Chojak, Lara Koutah, Noah B. Drewes, Sia Cho, Hasaan A Kazi, Rebecca Chen, Ella N. Perrault, Li Chen, Cheol H. Park, Maeve C. O’Shea, Khizar Rehan Nandoliya, Joseph T. Duffy, , A. Karim Ahmed
This study identifies THOC1 as a driver of glioblastoma progression by interacting with SIN3A to regulate R-loops and telomere stability.
Neoplasia · Jan 6, 2026Peer-reviewedCancer Biology