Author

Rafał Chojak

Northwestern UniversityORCID 0000-0002-7644-3444Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Adam M. SonabendiD· 3 shared Atique U. AhmediD· 2 shared Hasaan A Kazi· 2 shared Jason M. MiskaiD· 2 shared Kathleen McCortneyiD· 2 shared Lara KoutahiD· 2 shared Maciej S. LesniakiD· 2 shared Maeve C. O’Shea· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Adam M. SonabendORCID

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3 papers

Recent·Most cited

Temozolomide-associated inflammatory-repair remodeling in recurrent glioblastoma exposes a ROCK-linked therapeutic vulnerability

Rafał Chojak, Umme Habiba Faisal, Priya Kumthekar, Noah B. Drewes, Lara Koutah, Jessica Jia, Jillyn R Turunen, Maeve C. O’Shea, Victoria Falkowski, Ayaan Akhtar, Shu Wang, Justin Chen, Shanti Ahmed, Hasaan A Kazi, Brenda Auffinger, , Atique U. Ahmed

This study shows that preoperative temozolomide exposure in recurrent glioblastoma leads to inflammatory-repair remodeling and a ROCK-linked therapeutic vulnerability, which can be targeted by fasudil.

bioRxiv · Sep 22, 2026 · PreprintCancer Biology

Myeloid-targeted RNA nanotherapeutics rewire cholesterol metabolism to unleash anti-tumor immunity in glioblastoma

Jiawei Huo, Hanchen Lin, Yinmeng Li, Shashwat Tripathi, Rafał Chojak, Caylee Silvers, Yirui Peng, Lauren K. Boland, Jianzhong Zhang, Kathleen McCortney, Rasangi M. Perera, Hinda Najem, Leah K. Billingham, Tzu-Yi Chia, Xiaoyang Chen, , Peng Zhang

The paper develops RNA nanotherapeutics targeting TAMC cholesterol metabolism to enhance anti-tumor immunity in glioblastoma.

bioRxiv · Aug 7, 2026 · PreprintImmunology

THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression

Shreya Budhiraja, Umme H Faisal, Shivani Baisiwala, Rafał Chojak, Lara Koutah, Noah B. Drewes, Sia Cho, Hasaan A Kazi, Rebecca Chen, Ella N. Perrault, Li Chen, Cheol H. Park, Maeve C. O’Shea, Khizar Rehan Nandoliya, Joseph T. Duffy, , A. Karim Ahmed

This study identifies THOC1 as a driver of glioblastoma progression by interacting with SIN3A to regulate R-loops and telomere stability.

Neoplasia · Jan 6, 2026Peer-reviewedCancer Biology