Structural basis for the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair
Seung Kuk Park, Mo Guo, Jennifer L. Stamos, Wantae Kim, Sidae Lee, Yan Zhang, Alan M. Lambowitz
This study determines the structural basis for how a domesticated reverse transcriptase evolved to function in DNA repair by revealing key structural adaptations in its apoenzyme and DNA synthesis complexes.
Proceedings of the National Academy of Sciences · Jul 29, 2025Peer-reviewedMolecular Biology