Alan M. Lambowitz

This study visualizes G2L4 reverse transcriptase's role in DNA repair via microhomology-mediated end joining using high-speed atomic force microscopy.

This study determines the structural basis for how a domesticated reverse transcriptase evolved to function in DNA repair by revealing key structural adaptations in its apoenzyme and DNA synthesis complexes.

The paper identifies thousands of FLEXIs in human cells, links them to RNA-binding proteins, and suggests their potential as biomarkers.

The paper identifies mechanisms by which an RT-Cas1 fusion protein integrates RNA into DNA genomes through cDNA synthesis and site-specific integration.

This study uses TGIRT-seq to analyze IBC tumor and blood samples, revealing widespread transcriptional changes and RNA splicing impacts in plasma.

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

The paper identifies a bacterial group II intron-like reverse transcriptase involved in DNA repair via microhomology-mediated end joining.

The paper analyzes template switching by a group II intron reverse transcriptase, establishing kinetic parameters and identifying conditions for efficient acceptor RNA/DNA capture.

The paper improves TGIRT-seq methods by reducing adapter dimer formation and correcting 5- and 3-end biases, enhancing transcriptome coverage and library construction efficiency.

This study compares alignment-free and alignment-based RNA-seq pipelines for total RNA quantification, finding alignment-free tools less accurate for small and lowly-expressed RNAs.