Wantae Kim

Targeting Noncanonical TEAD Axis to Overcome DNA Repair-Driven Chemoresistance

This study identifies a noncanonical role of TEAD in DNA repair, showing it can be targeted to overcome chemoresistance in tumors.

NitrOFF: An engineered fluorescent biosensor to illuminate nitrate transport in living cells

The paper introduces NitrOFF, a fluorescent biosensor for real-time nitrate detection in mammalian cells, showing it responds to nitrate with a turn-off fluorescence mechanism.

Structural basis for the evolution of a domesticated group II intron-like reverse transcriptase to function in host cell DNA repair

This study determines the structural basis for how a domesticated reverse transcriptase evolved to function in DNA repair by revealing key structural adaptations in its apoenzyme and DNA synthesis complexes.

Synthetic microbial sensing and biosynthesis of amaryllidaceae alkaloids

The paper develops a biosensor-AI system to engineer E. coli for efficient production of amaryllidaceae alkaloids, achieving improved titer and reduced byproducts.

Using structurally fungible biosensors to evolve improved alkaloid biosyntheses

This paper evolves highly specific and sensitive biosensors for alkaloids using a combined screening and selection approach, enabling improved microbial production of therapeutic plant metabolites.