Author

Sigourney Bonner

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Elizabeth Alexandra CooperiD· 2 shared Jason EigenbroodiD· 2 shared Richard J. GilbertsoniD· 2 shared Adrian LevineiD· 1 shared Aidan E Cedillo· 1 shared Alberto DelaidelliiD· 1 shared Alexandra RasnitsyniD· 1 shared Amr M. SaadeldiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersDevelopmental Biology

Elizabeth Alexandra CooperORCID

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2 papers

Recent·Most cited

Ependymomas are cancers of the pre-neural crest/roof plate lineage

Polina Balin, Sachin A Kumar, Riley Galton, Alberto Delaidelli, Wilda Orisme, Parthiv Haldipur, Ncedile Mankahla, Amr M. Saadeldin, Nik von Krosigk, Maria Claudia Vladoiu, Anders Wilder Erickson, Meyer Barembaum, Jake Millman, Amy J Banks, Jeffrey T Joseph, , Michael D. Taylor

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

bioRxiv · Jul 14, 2026 · PreprintDevelopmental Biology

Childhood brain tumours instruct cranial haematopoiesis and immunotolerance

Elizabeth Alexandra Cooper, David A Posner, Colin Y.C. Lee, Linda Hu, Sigourney Bonner, Jessica Taylor, Oscar Baldwin, Rocío Jiménez‐Guerrero, Katherine Elizabeth Masih, Katherine Wickham-Rahrmann, Jason Eigenbrood, Gina Ngo, Luca Porcu, Valar Nila Roamio Franklin, Clive S. D’Santos, , Richard J. Gilbertson

This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.

bioRxiv · Sep 25, 2025 · PreprintImmunology

Sigourney Bonner · henhao