Childhood brain tumours instruct cranial haematopoiesis and immunotolerance
Elizabeth Alexandra Cooper, David A Posner, Colin Y.C. Lee, Linda Hu, Sigourney Bonner, Jessica Taylor, Oscar Baldwin, Rocío Jiménez‐Guerrero, Katherine Elizabeth Masih, Katherine Wickham-Rahrmann, Jason Eigenbrood, Gina Ngo, Luca Porcu, Valar Nila Roamio Franklin, Clive S. D’Santos, , Richard J. Gilbertson
This study identifies a mechanism by which skull bone marrow-derived HSPCs and CD4+ T cells promote immunotolerance in childhood brain tumours, showing that antibody therapy targeting CSF cytokines can disrupt this process and induce tumour regression.
bioRxiv · Sep 25, 2025 · PreprintImmunology