Author

Siham Hachi

University of Luxembourg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cell Biology· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Edinson Lucumi MorenoiD· 4 shared Jens Christian SchwamborniD· 3 shared Khalid I.W. Kane· 2 shared Ronan M. T. FlemingiD· 2 shared Thomas HankemeieriD· 2 shared Agnieszka B. WegrzyniD· 1 shared Alexander SkupiniD· 1 shared Alissa Schurink· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersSystems Biology

Edinson Lucumi MorenoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism

German Preciat, Agnieszka B. Wegrzyn, Edinson Lucumi Moreno, Cornelius C.W. Willacey, Jennifer Modamio, Fátima Liliana Monteiro, Diana Charles El Assal, Alissa Schurink, Miguel A. P. Oliveira, Zhi Zhang, Ben Cousins, Hulda S. Haraldsdóttir, Siham Hachi, Susanne Zach, Germán Leparc, , Ronan M. T. Fleming

The paper develops genome-scale metabolic models of human dopaminergic neurons to study metabolic dysfunction in Parkinson's disease using exometabolomic and transcriptomic data.

bioRxiv · Jun 30, 2021 · PreprintSystems Biology

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson's Disease

Edinson Lucumi Moreno, Siham Hachi, Sarah Nickels, Khalid I.W. Kane, Masha Moein, Jens Christian Schwamborn, Alexander Skupin, Pieter Vanden Berghe, Ronan M. T. Fleming

This study investigates neuronal activity in LRRK2-G2019S mutant neurons and finds increased spontaneous calcium transients and shorter inter-spike intervals.

bioRxiv · Jun 23, 2021 · PreprintNeuroscience

Automated microuidic cell culture of stem cell derived dopaminergic neurons in Parkinson’s disease

Khalid I.W. Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Thomas Hankemeier, Paul Vulto, Jens Schwamborn, Martin Thoma, Ronan M.T. Fleming

The paper describes an automated microfluidic platform for culturing Parkinson’s disease patient-derived dopaminergic neurons and validates its ability to monitor differentiation and neuronal activity.

bioRxiv · Oct 28, 2017 · PreprintBioengineering

A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells

Anna Sophia Monzel, Lisa Maria Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Ronan MT Fleming, Silvia Bolognin, Jens Christian Schwamborn

This paper introduces a novel method to generate midbrain-specific human organoids from neuroepithelial stem cells, which exhibit dopaminergic neurons, synaptic connections, and myelination, making them suitable for Parkinson's disease research.

Stem Cell Reports · May 1, 2017Peer-reviewedCell Biology