Edinson Lucumi Moreno

fluxTrAM: Integration of tracer-based metabolomics data into atomically resolved genome-scale metabolic networks for metabolic flux analysis

fluxTrAM automates processing of tracer-based metabolomics data and integrates it with genome-scale metabolic models for flux analysis.

Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies and classifies Parkinson-relevant pesticides

The paper combines epidemiological pesticide exposure data with iPSC-derived dopaminergic neuron screening to identify and classify pesticides linked to Parkinson's disease.

Mechanistic model-driven exometabolomic characterisation of human dopaminergic neuronal metabolism

The paper develops genome-scale metabolic models of human dopaminergic neurons to study metabolic dysfunction in Parkinson's disease using exometabolomic and transcriptomic data.

Neuronal hyperactivity in a LRRK2-G2019S cellular model of Parkinson's Disease

This study investigates neuronal activity in LRRK2-G2019S mutant neurons and finds increased spontaneous calcium transients and shorter inter-spike intervals.

Automated microuidic cell culture of stem cell derived dopaminergic neurons in Parkinson’s disease

The paper describes an automated microfluidic platform for culturing Parkinson’s disease patient-derived dopaminergic neurons and validates its ability to monitor differentiation and neuronal activity.

A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells

This paper introduces a novel method to generate midbrain-specific human organoids from neuroepithelial stem cells, which exhibit dopaminergic neurons, synaptic connections, and myelination, making them suitable for Parkinson's disease research.