Anna Sophia Monzel

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

The paper profiles mitochondrial phenotypes in immune cells of mitochondrial disease patients and finds they are largely preserved and not strongly linked to disease severity.

This study shows that electroconvulsive therapy (ECT) improves motor function in Parkinsonian mice by promoting dopaminergic axon regeneration and restoring striatal circuitry.

The paper examines mitochondrial distribution patterns across tissues and finds they lack coherence, suggesting tissue-specific and individualized regulatory mechanisms.

The paper integrates multi-modal data to identify shared molecular dysregulation across Parkinson's disease variants, finding common transcriptomic features in glial cells and potential involvement of ROBO signalling.

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

The paper examines mitochondrial respiratory chain capacity and its association with stress-related behaviors in mice, identifying brain networks linked to anxiety-like behavior.

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.

This paper introduces a novel method to generate midbrain-specific human organoids from neuroepithelial stem cells, which exhibit dopaminergic neurons, synaptic connections, and myelination, making them suitable for Parkinson's disease research.