Silvia Bolognin

Lab-on-a-chip device integrating a human stem cell-based blood-brain barrier model with neural organoids for translational research

This paper develops a lab-on-a-chip system integrating a human BBB model with neural organoids to study BBB function and nanoparticle transport, showing BBB integrity and nanoparticle entry into neural tissue.

Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids

This study uses human iPSC-derived cells to model replicative senescence in neural progenitors and shows it induces astrocyte senescence in 2D cultures and midbrain organoids, linking it to Parkinson's disease.

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

The paper uses single-cell RNA-sequencing to identify multiple neuronal cell types in human midbrain organoids, including dopaminergic, GABAergic, and glutamatergic neurons.

Parkinson’s disease phenotypes in patient specific brain organoids are improved by HP-β-CD treatment

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.

In Vivo Phenotyping Of Parkinson-Specific Stem Cells Reveals Increased a-Synuclein Levels But No Spreading

This study transplants Parkinson's patient iPSC-derived neurons into mice, finding increased alpha-Synuclein levels but no spreading in the mouse brain.

A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells

This paper introduces a novel method to generate midbrain-specific human organoids from neuroepithelial stem cells, which exhibit dopaminergic neurons, synaptic connections, and myelination, making them suitable for Parkinson's disease research.