Author

Silvia León

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Victor Manuel NavarroiD· 4 shared Chrysanthi FerganiiD· 3 shared Achi Gerutshang· 2 shared Anne M.J. VerstegeniD· 2 shared Rajae TalbiiD· 2 shared Allan Edward HerbisoniD· 1 shared Bradford B. LowelliD· 1 shared Caroline A. Maguire· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Victor Manuel NavarroORCID

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Author profile →

4 papers

Recent·Most cited

POMC neurons control fertility through differential signaling of MC4R in Kisspeptin neurons

Rajae Talbi, Todd L. Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol D. Walec, Elizabeth Medve, Achi Gerutshang, Silvia León, Elizabeth A McCarthy, Oline K. Rønnekleiv, Martin J. Kelly, Victor Manuel Navarro

This study shows that MC4R in Kiss1 neurons regulates female fertility by modulating GnRH pulse generation and preovulatory LH surge through distinct signaling mechanisms.

bioRxiv · Feb 18, 2024Neuroscience

NKB Signaling in the Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-Independent Manner in Female Mice

Chrysanthi Fergani, Silvia León, Stéphanie L. Padilla, Anne M.J. Verstegen, Richard D. Palmiter, Victor Manuel Navarro

This study shows that NKB signaling in the medial amygdala stimulates gonadotropin release in female mice independently of kisspeptin.

eLife · Dec 19, 2018Peer-reviewedNeuroscience

Redundancy in the central tachykinin systems safeguards puberty onset and fertility

Silvia León, Chrysanthi Fergani, Rajae Talbi, Serap Simavli, Caroline A. Maguire, Achi Gerutshang, Stephanie B. Seminara, Víctor M. Navarro

The paper shows that redundancy among tachykinins safeguards puberty and fertility in mice, with NKA compensating for NKB loss in females.

bioRxiv · Oct 15, 2018 · PreprintPhysiology

PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

Rachel Ross, Silvia León, Joseph C. Madara, Danielle M. Schafer, Chrysanthi Fergani, Caroline Maguire, Anne M.J. Verstegen, Emily Brengle, Dong Kong, Allan Edward Herbison, Ursula B. Kaiser, Bradford B. Lowell, Victor Manuel Navarro

This study identifies PACAP-expressing neurons in the ventral premammillary nucleus that regulate reproductive function in female mice by modulating kisspeptin neurons.

eLife · Jun 15, 2018Peer-reviewedNeuroscience